14.12 Red cell folate (categories)
Within reference ranges (360 to 1400 vs >1400).
14.12.1 Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 310.796656 | 1 | <0.0001 | *** |
| rcfolate_gp | 0.792747 | 1 | 0.4 | ns |
| GA_samp | 92.716282 | 1 | <0.0001 | *** |
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 33.7346509 | 1 | <0.0001 | *** |
| rcfolate_gp | 0.3751633 | 1 | 0.5 | ns |
| GA_samp | 1668.8334228 | 1 | <0.0001 | *** |
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 554.223806 | 1 | <0.0001 | *** |
| rcfolate_gp | 4.402085 | 1 | 0.04 | * |
| GA_samp | 774.499623 | 1 | <0.0001 | *** |
| model term | df1 | df2 | F.ratio | Chisq | p.value | |
|---|---|---|---|---|---|---|
| rcfolate_gp | 1 | Inf | 3.454 | 3.454 | 0.06 | ns |
| GA_samp | 1 | Inf | 3.104 | 3.104 | 0.08 | ns |
| model term | df1 | df2 | F.ratio | Chisq | p.value | |
|---|---|---|---|---|---|---|
| rcfolate_gp | 1 | Inf | 3.124 | 3.124 | 0.08 | ns |
| GA_samp | 1 | Inf | 2.451 | 2.451 | 0.1 | ns |
| model term | df1 | df2 | F.ratio | Chisq | p.value | |
|---|---|---|---|---|---|---|
| rcfolate_gp | 1 | Inf | 2.923 | 2.923 | 0.09 | ns |
| GA_samp | 1 | Inf | 0.679 | 0.679 | 0.4 | ns |
14.12.2 Model summary
Ratio of Geometric means (95% CI)
| Var | Effect | P |
|---|---|---|
| (Intercept) | 18.02 (13.07, 24.84) | <0.0001 |
| rcfolate_gp>1400 | 1.04 (0.96, 1.12) | 0.37 |
| GA_samp | 1.13 (1.10, 1.16) | <0.0001 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 1.70 (1.42, 2.04) | <0.0001 |
| rcfolate_gp>1400 | 0.99 (0.94, 1.03) | 0.54 |
| GA_samp | 1.36 (1.34, 1.38) | <0.0001 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 0.06 (0.05, 0.07) | <0.0001 |
| rcfolate_gp>1400 | 0.93 (0.88, 1.00) | 0.04 |
| GA_samp | 1.33 (1.30, 1.35) | <0.0001 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 7.78 (5.31, 11.41) | <0.0001 |
| rcfolate_gp>1400 | 1.10 (0.99, 1.23) | 0.06 |
| GA_samp | 1.03 (1.00, 1.07) | 0.08 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 1.68 (1.12, 2.51) | 0.01 |
| rcfolate_gp>1400 | 1.10 (0.99, 1.23) | 0.08 |
| GA_samp | 1.03 (0.99, 1.07) | 0.12 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 4.83 (4.51, 5.17) | <0.0001 |
| rcfolate_gp>1400 | 1.02 (1.00, 1.04) | 0.09 |
| GA_samp | 1.00 (0.99, 1.00) | 0.41 |
14.12.3 Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)
Diagnositcs for hPL (μg/ml)
Diagnositcs for GH2 (ng/ml)
Diagnositcs for Insulin (uU/ml)
Diagnositcs for HOMA-IR
Diagnositcs for Glucose (mmol/L)
14.12.4 Estimated marginal means
| Outcome | rcfolate_gp | response | SE | df | lower.CL | upper.CL |
|---|---|---|---|---|---|---|
| PRL (ng/ml) | 360 to 1400 | 74.124 | 5.629 | 72.984 | 63.712 | 86.237 |
| PRL (ng/ml) | >1400 | 76.868 | 5.697 | 66.388 | 66.297 | 89.125 |
| hPL (μg/ml) | 360 to 1400 | 58.879 | 1.899 | 74.820 | 55.214 | 62.787 |
| hPL (μg/ml) | >1400 | 58.014 | 1.786 | 62.513 | 54.551 | 61.696 |
| GH2 (ng/ml) | 360 to 1400 | 1.502 | 0.053 | 115.968 | 1.400 | 1.611 |
| GH2 (ng/ml) | >1400 | 1.404 | 0.047 | 89.453 | 1.315 | 1.500 |
| Insulin (uU/ml) | 360 to 1400 | 10.962 | 0.424 | Inf | 10.163 | 11.825 |
| Insulin (uU/ml) | >1400 | 12.107 | 0.445 | Inf | 11.265 | 13.012 |
| HOMA-IR | 360 to 1400 | 2.312 | 0.094 | Inf | 2.135 | 2.504 |
| HOMA-IR | >1400 | 2.555 | 0.099 | Inf | 2.367 | 2.757 |
| Glucose (mmol/L) | 360 to 1400 | 4.703 | 0.042 | Inf | 4.622 | 4.785 |
| Glucose (mmol/L) | >1400 | 4.799 | 0.038 | Inf | 4.726 | 4.873 |
14.12.6 Post-hoc comparisons
| Outcome | Contrast | Ratio of Geometric means (95% CI) | P-value |
|---|---|---|---|
| PRL (ng/ml) | >1400 / 360 to 1400 | 1.04 (0.96, 1.12) | 0.4 |
| hPL (μg/ml) | >1400 / 360 to 1400 | 0.99 (0.94, 1.03) | 0.5 |
| GH2 (ng/ml) | >1400 / 360 to 1400 | 0.93 (0.88, 1.00) | 0.04 |
| Insulin (uU/ml) | >1400 / 360 to 1400 | 1.10 (0.99, 1.23) | 0.06 |
| HOMA-IR | >1400 / 360 to 1400 | 1.10 (0.99, 1.23) | 0.08 |
| Glucose (mmol/L) | >1400 / 360 to 1400 | 1.02 (1.00, 1.04) | 0.09 |